Verify Account

Introduction: Biopharmaceutics
Absorption: Mechanisms of drug absorption through GIT, factors influencing drug absorption through GIT, absorption of drug from non per oral extravascular routes.
Distribution: Tissue permeability of drugs, binding of drugs, apparent volume of drug distribution, plasma and tissue protein binding of drugs, factors affecting protein-drug binding, kinetics of protein binding, clinical significance of protein binding of drugs.

Elimination: Drug metabolism and basic understanding of metabolic pathways. Renal excretion of drugs, factors affecting renal excretion of drugs, renal clearance, non-renal routes of drug excretion.
Bioavailability and Bioequivalence: Definition and objectives of bioavailability, absolute and relative bioavailability, measurement of bioavailability, in vitro drug dissolution models, in vitro-in vivo correlations, bioequivalence studies, methods to enhance the dissolution rates and bioavailability of poorly soluble drugs.

Pharmacokinetics: Definition and introduction to pharmacokinetics, compartment models, non-compartment models, physiological models, one compartment open model. (a) Intravenous injection (bolus)
(b) Intravenous infusion
(c) Extra-vascular administrations.
Pharmacokinetics Parameters - KE, t½, Vd, AUC, Ka, ClT and ClR-definitions, methods of elimination, understanding of their significance and applications.

Multicompartment Models Two compartment open model-i.v bolus, kinetics of multiple dosing, steady state drug levels, calculation of loading and maintenance doses and their significance in clinical settings.

Non-linear Pharmacokinetics: (a) Introduction
(b) Factors causing non-linearity
(c) Michaelis-Menten method of estimating parameters, explanation with example of drugs.