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SYLLABUS

Unit-I

Antihistaminic agents: Histamine, receptors and their distribution in the human body. H1 –antagonists: Diphenhydramine hydrochloride*, dimenhydrinate, doxylamine succinate, clemastine fumarate, diphenylphyraline hydrochloride, tripelennamine hydrochloride, chlorcyclizine hydrochloride, meclizine hydrochloride, buclizine hydrochloride, chlorpheniramine maleate, triprolidine hydrochloride*, phenindamine tartarate, promethazine hydrochloride*, trimeprazine tartrate, cyproheptadine hydrochloride, azatidine maleate, astemizole, loratadine, cetirizine, levocetirizine, cromolyn sodium. H2 -antagonists: Cimetidine*, famotidine, ranitidine. Gastric Proton Pump Inhibitors: Omeprazole, lansoprazole, rabeprazole, pantoprazole. Antineoplastic Agents Alkylating Agents: Meclorethamine*, cyclophosphamide, melphalan, chlorambucil, busulfan, thiotepa Antimetabolites: Mercaptopurine*, thioguanine, fluorouracil, floxuridine, cytarabine, methotrexate*, azathioprine. Antibiotics: Dactinomycin, daunorubicin, doxorubicin, bleomycin. Plant Products: Etoposide, vinblastin sulphate, vincristin sulphate. Miscellaneous: Cisplatin, Mitotane.

Unit-II

Antianginals Vasodilators: Amyl nitrite, nitroglycerine*, pentaerythritol tetranitrate, isosorbide dinitrite*, dipyridamole. Calcium Channel Blockers: Verapamil, bepridil hydrochloride, diltiazem hydrochloride, nifedipine, amlodipine, felodipine, nicardipine, nimodipine. Diuretics Carbonic Anhydrase Inhibitors: Acetazolamide*, methazolamide, dichlorphenamide. Thiazides: Chlorthiazide*, hydrochlorthiazide, hydroflumethiazide, cyclothiazide. Loop Diuretics: Furosemide*, bumetanide, ethacrynic acid. Potassium Sparing Diuretics: Spironolactone, triamterene, amiloride. Osmotic Diuretics: Mannitol. Antihypertensive Agents: Timolol, captopril, lisinopril, enalapril, benazepril hydrochloride, quinapril hydrochloride, methyldopate hydrochloride, clonidine hydrochloride, guanethidine monosulphate, guanabenz acetate, sodium nitroprusside, diazoxide, minoxidil, reserpine, hydralazine hydrochloride.

Unit-III

Antiarrhythmic Drugs: Quinidine sulphate, procainamide hydrochloride, disopyramide phosphate*, phenytoin sodium, lidocaine hydrochloride, tocainide hydrochloride, mexiletine hydrochloride, lorcainide hydrochloride, amiodarone, sotalol. Antihyperlipidemic Agents: Clofibrate, lovastatin, cholestyramine and cholestipol. Coagulant & Anticoagulants: Menadione, acetomenadione, warfarin*, anisindione, clopidogrel. Drugs Used in Congestive Heart Failure: Digoxin, digitoxin, nesiritide, bosentan, tezosentan.

Unit-IV

Drugs Acting on Endocrine System: Nomenclature, stereochemistry and metabolism of steroids. Sex Hormones: Testosterone, nandrolone, progestrone, oestriol, oestradiol, oestrione, diethyl stilbestrol. Drugs for Erectile Dysfunction: Sildenafil, tadalafil. Oral Contraceptives: Mifepristone, norgestrel, levonorgestrel. Corticosteroids: Cortisone, hydrocortisone, prednisolone, betamethasone, dexamethasone. Thyroid and Antithyroid Drugs: l-thyroxine, l-thyronine, propylthiouracil, methimazole.

Unit-V

Antidiabetic Agents: Insulin and its preparations. Sulfonylureas: Tolbutamide*, chlorpropamide, glipizide, glimepiride. Biguanides: Metformin. Thiazolidinediones: Pioglitazone, rosiglitazone. Meglitinides: Repaglinide, nateglinide. Glucosidase inhibitors: Acarbose, voglibose. Local Anaesthetics: SAR of local anesthetics Benzoic Acid Derivatives: Cocaine, hexylcaine, meprylcaine, cyclomethycaine, piperocaine. Amino Benzoic acid derivatives: Benzocaine*, butamben, procaine*, butacaine, propoxycaine, tetracaine, benoxinate. Lidocaine/Anilide derivatives: Lignocaine, mepivacaine, prilocaine, etidocaine. Miscellaneous: Phenacaine, diperodon, dibucaine.*